Penegra 50 mg (sildenafil) can cause low blood pressure (hypotension) in certain situations — especially when its blood‑vessel‑relaxing effects are amplified. Normally, sildenafil mildly widens blood vessels and can slightly lower blood pressure, but this is usually not dangerous on its own in healthy people. When Penegra 50 mg Can Cause Low Blood Pressure   With Nitrate Medications Taking Penegra with nitrates (medicines like nitroglycerin or isosorbide used for chest pain/angina) can cause a severe and dangerous drop in blood pressure — potentially life‑threatening. This combination is contraindicated and must be avoided. With Other Blood‑Pressure‑Lowering Drugs Using Penegra along with alpha‑blockers or other antihypertensive medications can produce additive effects, increasing the risk of symptomatic hypotension (dizziness or fainting). In Sensitive Individuals People who already have low baseline blood pressure, are dehydrated, or have serious heart conditions may be more prone to noticeable drops in blood pressure after taking sildenafil.  Around Peak Effect Time The greatest blood‑pressure‑lowering effect tends to occur 1–2 hours after taking the tablet, when sildenafil levels in the blood are highest.