Vidalista 40 mg (a high‑strength Tadalafil tablet) is most effective when taken about 30–60 minutes before planned sexual activity. This timing gives the medication enough time to start working, and its effect can then last up to 36 hours — offering a long window during which erections may be achieved with sexual stimulation.  When Vidalista 40 mg Works Best 30–60 minutes before sex: This is the typical recommended time to take it so that it reaches peak activity around when you want it to work. Within the next 36 hours: Once active in your system, the medication provides enhanced erectile response any time you are sexually stimulated during this period — this flexibility is why it’s sometimes called the “weekend pill.” Empty stomach or light meal: Taking Vidalista on a relatively empty stomach (or after a light meal) may help it kick in faster; heavy or fatty meals can delay absorption. Only with sexual stimulation: Vidalista doesn’t cause automatic erections — arousal is required for the effect.